![]() ![]() The aim of the current study was to evaluate whether HBOT affects cognitive function and brain perfusion in normal, non-pathological, aging adults.īaseline comparison p-value tests the null hypothesis of equal means of the two groups at the baseline using an unpaired t-test 3 months comparison p-value tests the null hypothesis of equal means of each group pre-post intervention (HBOT/control respectively) using a paired t-test.īold - P<0.05, *Satisfied Bonferroni corrections. However, no study to date has examined HBOT’s neurocognitive effects in normal aging populations. There is growing evidence from clinical studies that HBOT, utilized in a repeated daily sessions protocol, has neurotherapeutic effects which can improve cognitive functions in post-stroke, traumatic brain injury and anoxic brain damaged patients even years after the acute insult. In turn, neovascularization can enhance cerebral blood flow and consequently improve the metabolic activity. Angiogenesis is induced mainly in brain regions signaling ischemia or metabolic dysfunction. Repeated intermittent hyperoxic exposures, has been shown to induce physiological effects which normally occur during hypoxia in a hyperoxic environment, including stem cells proliferation and generation of new blood vessels (angiogenesis). Hyperbaric oxygen therapy (HBOT) utilizes 100% oxygen in an environmental pressure higher than one absolute atmospheres (ATA) to enhance the amount of oxygen dissolved in body’s tissues. Unfortunately, so far, pharmacological interventions did not show significant improvements in cognitive performance in normal aging, and have significant risks for side effects. Non pharmacological lifestyle interventions including exercise, healthy diets and cognitive training have shown positive effects if intensively performed. Ī growing body of research suggests several methods for cognitive enhancement and for improving the quality of life in both healthy and pathological states. Although not associated with a specific pathology, reduced regional CBF is associated with impaired cognitive functions. Cerebrovascular dysfunction is an additional distinctive feature of aging that includes endothelial-dependent vasodilatation and regional decreases in cerebral blood flow (CBF). Processing speed, conceptual reasoning, memory and problem-solving activities are the main domains which decline gradually over time. Besides common pathological declines such as in Alzheimer’s dementia and mild cognitive impairments, normal cognitive aging is part of the normal aging process. More than half of community-dwelling individuals, sixty years and older, express concern about declining cognitive abilities. The main improvements include attention, information processing speed and executive functions, which normally decline with aging. In this study, HBOT was shown to induce cognitive enhancements in healthy aging adults via mechanisms involving regional changes in CBF. Voxel-based analysis showed significant cerebral blood flow increases in the HBOT group compared to the control group in the right superior medial frontal gyrus (BA10), right and left supplementary motor area (BA6), right middle frontal gyrus (BA6), left middle frontal gyrus (BA9), left superior frontal gyrus (BA8) and the right superior parietal gyrus (BA7). The most striking improvements were in attention (net effect size=0.745) and information processing speed (net effect size=0.788). There was a significant group-by-time interaction in global cognitive function post-HBOT compared to control (p=0.0017). Cerebral blood flow (CBF) was evaluated by perfusion magnetic resonance imaging. Primary endpoint included the general cognitive function measured post intervention/control. The current study’s aim was to evaluate hyperbaric oxygen therapy (HBOT) effect on cognitive functions in healthy aging adults.Ī randomized controlled clinical trial randomized 63 healthy adults (>64) either to HBOT(n=33) or control arms(n=30) for three months. More than half of community-dwelling individuals sixty years and older express concern about declining cognitive abilities. 6 Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel.5 Research and Development Unit, Shamir Medical Center, Zerifin, Israel.4 Radiology Department, Shamir Medical Center, Zerifin, Israel.3 The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel.2 Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.1 The Sagol Center for Hyperbaric Medicine and Research, Shamir (Assaf-Harofeh) Medical Center, Zerifin, Israel.Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial ![]()
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